Animal models of pulmonary emphysema: a stereologist’s perspective
نویسنده
چکیده
A variety of animal models have been suggested as models of pulmonary emphysema; these are critically discussed in the present article from a stereologist’s perspective. In addition, a stereological design for the quantification of experimentally induced emphysema is
منابع مشابه
Animal models of emphysema: the next generations.
Niewoehner (1) wrote in 1988 that pulmonary emphysema is one of the most important causes of morbidity and mortality in our modern society, and his statement rings just as true today as it did then. Progress in the intervening years has built on the creation and analysis of animal models for this disease, many of which, including the one described by Zheng et al. (2) in a recent issue of the JC...
متن کاملChronic obstructive pulmonary disease * 3: Experimental animal models of pulmonary emphysema.
The use of genetically manipulated mice together with traditional animal studies are steadily increasing our knowledge of the factors important in determining alveolar formation and destruction in emphysema. A review of the animal models used to study emphysema is presented.
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OBJECTIVES To review the animal models of COPD, and to compare these data to those found in humans. RESULTS Smoke-induced animal models can produce emphysema, although the lesions are not generally close mimics of human emphysema, as well as increases in mucous-secreting cells and vascular changes including pulmonary hypertension. There is considerable species-to-species variation in the degr...
متن کاملMechanisms of cigarette smoke-induced COPD: insights from animal models.
Cigarette smoke-induced animal models of chronic obstructive pulmonary disease support the protease-antiprotease hypothesis of emphysema, although which cells and proteases are the crucial actors remains controversial. Inhibition of either serine or metalloproteases produces significant protection against emphysema, but inhibition is invariably accompanied by decreases in the inflammatory respo...
متن کاملInvited Review ANIMAL MODELS OF HUMAN LUNG DISEASE Animal models of chronic obstructive pulmonary disease
Wright JL, Cosio M, Churg A. Animal models of chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 295: L1–L15, 2008. First published May 2, 2008; doi:10.1152/ajplung.90200.2008.—The mechanisms involved in the genesis of chronic obstructive pulmonary disease (COPD) are poorly defined. This area is complicated and difficult to model because COPD consists of four separate ana...
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